BJH - volume 11, issue Abstract Book BHS, february 2020
S. Servais MD, PhD, F. Baron MD, PhD, C. Lechanteur PhD, E. Baudoux MD, A. Briquet PhD, D. Selleslag MD, J. Maertens MD, PhD, X. Poiré MD, W. Schroyens MD, PhD, C. Graux MD, PhD, A. De Becker MD, R. Schots MD, PhD, P. Zachée MD, PhD, A. Ory , J. Herman , T. Kerre MD, PhD, Y. Beguin MD, PhD
BJH - volume 11, issue 1, february 2020
A. De Becker MD
This article will summarise the key studies in the field of acute leukaemia presented at the 2019 annual meeting of the American Society of Hematology (ASH). The selected abstracts in the field of acute myeloid leukaemia (AML) mainly focus on precision medicine, measurable residual disease (MRD) and maintenance treatment. In addition, results of the phase I trial using CD19/CD22 bispecific CAR T cells in paediatric and adult patients with acute lymphoblastic leukaemia (ALL) will be discussed.
(BELG J HEMATOL 2020;11(1):18–20)
Read moreBJH - volume 10, issue Abstract Book BHS, february 2019
A. De Becker MD, R. Schots MD, PhD, T. Kerre MD, PhD, D. Mazure , J. Maertens MD, PhD, E. Baudoux , C. Lechanteur , Y. Beguin MD, PhD
BJH - volume 9, issue 5, september 2018
A. Van de Velde MD, B. Willekens , L. Vanopdenbosch MD, O. Deryck , D. Selleslag MD, M. D’Haeseleer , A. De Becker MD, B. Dubois MD, PhD, D. Dierickx MD, PhD, G. Perrotta , V. De Wilde MD, PhD, V. Van Pesch MD, PhD, N. Straetmans MD, PhD, D. Dive MD, Y. Beguin MD, PhD, B. Van Wijmeersch MD, PhD, K. Theunissen , T. Kerre MD, PhD, G. Laureys MD, PhD
Multiple sclerosis is considered to be an immune mediated inflammatory disorder of the central nervous system. It mainly affects young, socioeconomic active patients. Although our armamentarium for this disease has significantly evolved in recent years some patients remain refractory to conventional therapies. In these cases, autologous haematopoietic stem cell transplantation can be considered as a therapeutic option. Decreasing morbidity, mortality and increasing patient awareness have led to rising inquiry by our patients about this treatment option. With the aim of a standardised protocol and data registration, a Belgian working party on stem cell therapy in multiple sclerosis was established. In this paper, we report the consensus protocol of this working party on autologous haematopoietic stem cell transplantation in multiple sclerosis.
(BELG J HEMATOL 2018;9(5):167–74)
Read moreBJH - volume 9, issue 4, august 2018
A. De Becker MD
The treatment modalities in the field of acute leukemia have seen spectacular changes in recent years. The introduction of chimeric antigen receptor T-cells (CAR T-cells) and bispecific T-cell engagers (BiTEs) dramatically improved the outcome of heavily pretreated patients with B-cell acute lymphoblastic leukemia (B-ALL). For the treatment of acute myeloid leukemia (AML), immunotherapy is more difficult to design, but also in this setting progress has been made. This text will describe recent advances in the field of acute leukemia presented at the latest EHA meeting.
(BELG J HEMATOL 2018;9(4):148–51)
Read moreBJH - volume 9, issue 1, february 2018
A. De Becker MD
When considering a stem cell transplantation for a patient, many factors come in to play, especially in case of an allogeneic stem cell transplantation (allo SCT). The best donor and source of stem cells should be selected, the type of conditioning must be considered and the type of underlying disease and disease status at transplant also have an impact on the outcome of the transplantation. Additionally, survival post-transplant is influenced by the occurrence of graft versus host disease (GVHD), infections, or relapsed disease. Advances in different areas of allo SCT reported at the 2017 Annual Meeting of the American Society of Hematology (ASH) will be discussed in this summary.
(BELG J HEMATOL 2018;9(1):41–3)
Read moreBJH - volume 8, issue Abstract Book BHS, february 2017
X. Poiré MD, C. Graux MD, PhD, A. Ory , J. Jamart , F. Frédéric , H. Schoemans MD, PhD, P. Lewalle MD, PhD, A. De Becker MD, D. Deeren , Z. Berneman MD, PhD, T. Kerre MD, PhD, P. Zachée MD, PhD, D. Selleslag MD, Y. Beguin MD, PhD
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