Articles

BHS clinical guidelines on the management of acute complications in sickle cell disease

BJH - volume 10, issue 4, june 2019

T. van Genechten MD, A. Vanderfaeillie MD, M.A. Azerad MD, D. Kieffer PhD, PharmD, V. Labarque MD, PhD, B. Gulbis MD, PhD, A. Ferster MD, PhD, B. De Wilde MD, PhD

With the increasing prevalence of sickle cell disease patients in Western countries, it is of importance to improve awareness among medical doctors of its complications. To reduce long-term morbidity and mortality, the prompt recognition and treatment of acute complications is important. The existing clinical guideline ‘Follow-up and treatment of patients with sickle cell disease hospitalised for Vaso Occlusive Crisis or infection’, published in 2012 by the Belgian Haematological Society, was revisited to better suit the practical needs of first-line practitioners.

(BELG J HEMATOL 2019;10(4):165–8)

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P37 CD123 expression on acute leukemia blasts, hematogones, and monocytes; used as Minimal Residual Disease Marker

BJH - volume 8, issue Abstract Book BHS, february 2017

L. Rozen PharmD, L. Mekkaoui , C. Rassart , A. Janssens MD, PhD, D. Bron MD, PhD, A. Ferster MD, PhD, B. Cantinieaux

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A-103 VALIDATION OF A CHROMOGENIC ASSAY FOR FVIII: C AND FIX: C (CSA) MEASURING AND COMPARISON WITH A CHRONOMETRIC ASSAY (OSA)

BJH - volume 8, issue Abstract Book BSTH, february 2017

C. Haeseleer , A. Demulder MD, PhD, P.-Q. Le , A. Hunanyan , A. Ferster MD, PhD, L. Rozen PharmD

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Endogenous thrombin generation potential: an added value parameter to individualize prophylaxis treatment in pediatric haemophiliac patients?

BJH - 2014, issue Abstract Book BSTH, november 2014

E. Pizzuti , L. Rozen PharmD, P.-Q. Le , A. Ferster MD, PhD, A. Demulder MD, PhD

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Minimal residual disease quantification by PCR in childhood acute lymphoblastic leukaemia

BJH - volume 5, issue 3, september 2014

J. Van Der Straeten MSc, B. De Moerloose MD, PhD, M-F. Dresse MD, PhD, S. Dupont MD, A. Ferster MD, PhD, P. Philippet MD, A. Uyttebroeck MD, PhD, J. van der Werff ten Bosch MD, PhD, C. Demanet MD, PhD, Y Benoit MD, PhD, M. Bakkus PhD

Summary

In Belgium approximately 70 children are diagnosed with acute lymphoblastic leukaemia annually. For these children, the monitoring of minimal residual disease has an important prognostic value. The level of minimal residual disease during the first three months of therapy is used to recognise subgroups that differ substantially in outcome. Two techniques are used for minimal residual disease monitoring: the Genescan method and the allele specific oligonucleotide polymerase chain reaction. The Genescan method is a less sensitive method (10−3) but is fast and less expensive. The allele specific oligonucleotide polymerase chain reaction requires more time and budget but has a sensitivity of 10−4–10−5. Both techniques have proven their value in minimal residual disease monitoring in childhood acute lymphoblastic leukaemia.

(BELG J HEMATOL 2014;5(3):81–8)

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Management of Sickle Cell Disease

BJH - volume 5, issue Abstract Book BHS, january 2014

A. Ferster MD, PhD

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P2.09 Impact of minimal residual disease monitoring on therapy in Belgian childhood acute lymphoblastic leukaemia

BJH - volume 5, issue Abstract Book BHS, january 2014

J. Van Der Straeten MSc, B. De Moerloose MD, PhD, M-F. Dresse MD, PhD, S. Dupont MD, A. Ferster MD, PhD, P. Philippet MD, A. Uyttebroeck MD, PhD, J. Van der Werf ten Bosch , C. Demanet MD, PhD, Y Benoit MD, PhD, M. Bakkus PhD

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