BJH - volume 9, issue Multiple Myeloma Special Edition, december 2018
A. Van de Velde MD, M. Timmers , P. Vlummens MD, S. Anguille MD, PhD
New therapeutic antibodies and T cells redirected to specific antigen targets with engineered chimeric antigen receptors (CARs) are emerging as powerful therapies in haematologic malignancies and multiple myeloma (MM). Various designs, manufacturing processes, and study populations, among other variables, have been tested and reported in clinical trials in MM. Here, we review and compare ongoing trials and the results of the reported clinical trials. We also discuss the outlook for CAR-T cell therapies, including managing toxicities and expanding the availability of personalized cell therapy as a promising approach to all haematologic malignancies.
Read moreBJH - volume 9, issue 5, september 2018
A. Van de Velde MD, B. Willekens , L. Vanopdenbosch MD, O. Deryck , D. Selleslag MD, M. D’Haeseleer , A. De Becker MD, B. Dubois MD, PhD, D. Dierickx MD, PhD, G. Perrotta , V. De Wilde MD, PhD, V. Van Pesch MD, PhD, N. Straetmans MD, PhD, D. Dive MD, Y. Beguin MD, PhD, B. Van Wijmeersch MD, PhD, K. Theunissen , T. Kerre MD, PhD, G. Laureys MD, PhD
Multiple sclerosis is considered to be an immune mediated inflammatory disorder of the central nervous system. It mainly affects young, socioeconomic active patients. Although our armamentarium for this disease has significantly evolved in recent years some patients remain refractory to conventional therapies. In these cases, autologous haematopoietic stem cell transplantation can be considered as a therapeutic option. Decreasing morbidity, mortality and increasing patient awareness have led to rising inquiry by our patients about this treatment option. With the aim of a standardised protocol and data registration, a Belgian working party on stem cell therapy in multiple sclerosis was established. In this paper, we report the consensus protocol of this working party on autologous haematopoietic stem cell transplantation in multiple sclerosis.
(BELG J HEMATOL 2018;9(5):167–74)
Read moreBJH - 2018, issue Abstract Book BHS, february 2018
K. Saevels MD, A. Van de Velde MD, S. Anguille MD, PhD, A. Verlinden MD, A. Gadisseur MD, PhD, W. Schroyens MD, PhD, Z. Berneman MD, PhD
BJH - 2018, issue Abstract Book BHS, february 2018
A. Devos , P. Maes , H. Daenens , K. Saevels MD, A. Van de Velde MD
BJH - volume 7, issue Abstract Book BHS, january 2016
N.C. Granacher MD, L. Rutsaert MD, Z. Berneman MD, PhD, W. Schroyens MD, PhD, L. Lammertijn , A. Van de Velde MD, A. Verlinden MD, A. Gadisseur MD, PhD
BJH - volume 6, issue Abstract Book BHS, january 2015
A. Van de Velde MD, S. Anguille MD, PhD, P. Beutels , S. Dom , I. Cornille , G. Nijs , F. van Tendeloo , E.L. Smits , A. Verlinden MD, A.P. Gadisseur , W.A. Schroyens , Z.N. Berneman MD, PhD
BJH - volume 6, issue Abstract Book BHS, january 2015
A. Mermikides , M. Mermikides , A. Tanczos , R. Seymour , A. Kirkham , C. Lofthouse , A. Nasrat , E. Weitkamp , A. Van de Velde MD
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