BJH - volume 6, issue Abstract Book BHS, january 2015
K. Vanhouteghem PharmD, B. Cauwelier MD, PhD, P. Costers , D. Selleslag MD, J. Emmerechts MD, PhD
BJH - volume 5, issue 4, december 2014
B. Depreter PharmD, E. Dumoulin PharmD, J. Billiet MD, B. Cauwelier MD, PhD, B. Maes MD, PhD, C. Matthys MD, J. Van Droogenbroeck MD, PhD, F. Nollet PhD, J. Emmerechts MD, PhD
We report a rare case of biclonal biphenotypic B-cell lymphocytosis with chronic lymphocytic leukaemia phenotype. Clonality was initially misjudged by immunophenotyping because of its polyphenotypic pattern. Polymerase chain reaction analysis revealed clonality of the immunoglobulin heavy chain and kappa light chain gene rearrangement, indicating the presence of a monoclonal B-lymphocyte population. Immunophenotyping was repeated after cell sorting and revealed two CD5+CD19+ populations with different light chain restriction. Different genetic abnormalities for both clones, as evidenced by fluorescence in situ hybridisation and hypermutation analysis, support the diagnosis of two independently originated but co-existing B-cell clones. This case illustrates the importance of using multiple techniques in the diagnostic work-up of haematological malignancies.
(BELG J HEMATOL 2014;5(4):143–7)
Read moreBJH - volume 5, issue Abstract Book BHS, january 2014
B. Depreter PharmD, F. Nollet PhD, S. Vermeire , B. Cauwelier MD, PhD, A. Van Hoof MD, PhD, J. Billiet MD
BJH - volume 5, issue Abstract Book BHS, january 2014
B. Cauwelier MD, PhD, W. Rosseel , F. Nollet PhD, W. Schroyens MD, PhD, A. Gadisseur MD, PhD, Z. Berneman MD, PhD
BJH - 2013, issue BHS Abstractbook, january 2013
K. de Keersmaecker , Z. Kalender Atak , N. Li , C. Vicente , S. Patchett , T. Girardi , V. Gianfelici , E. Geerdens , M. Porcu , I. Lahortiga , R. Luca , J. Yan , G. Hulselmans , E. Clappier , R. Vandepoel , B. Sweron , K. Jacobs PhD, N. Mentens , I. Wlodarska , B. Cauwelier MD, PhD, J. Cloos , J. Soulier , A. Uyttebroeck MD, PhD, C. Bagni , B. Hassan , P. Vandenberghe MD, PhD, A. Johnson , S. Aerts , J. Cools
BJH - 2013, issue BHS Abstractbook, january 2013
C. Vicente , K. de Keersmaecker , Z. Kalender Atak , J. Yan , N. Li , V. Gianfelici , E. Geerdens , E. Clappier , G. Hulselmans , R. Vande poel , B. Cauwelier MD, PhD, J. Cloos , J. Soulier , A. Uyttebroeck MD, PhD, B. Hassan , P. Vandenberghe MD, PhD, S. Aerts , J. Cools
BJH - 2013, issue BHS Abstractbook, january 2013
B.A.P.M. Depreter , J. Emmerechts MD, PhD, B. Cauwelier MD, PhD
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