BJH - volume 10, issue 4, june 2019
T. van Genechten MD, A. Vanderfaeillie MD, M.A. Azerad MD, D. Kieffer PhD, PharmD, V. Labarque MD, PhD, B. Gulbis MD, PhD, A. Ferster MD, PhD, B. De Wilde MD, PhD
With the increasing prevalence of sickle cell disease patients in Western countries, it is of importance to improve awareness among medical doctors of its complications. To reduce long-term morbidity and mortality, the prompt recognition and treatment of acute complications is important. The existing clinical guideline ‘Follow-up and treatment of patients with sickle cell disease hospitalised for Vaso Occlusive Crisis or infection’, published in 2012 by the Belgian Haematological Society, was revisited to better suit the practical needs of first-line practitioners.
(BELG J HEMATOL 2019;10(4):165–8)
Read moreBJH - volume 9, issue 4, august 2018
B. Gulbis MD, PhD
Red blood cell pathologies were highlighted during the congress. In particular, the Topics-in-Focus program put the spotlight on haemoglobinopathies. As in oncology, these heterogeneous (very) rare diseases also benefit from new tools for their diagnosis and from new or evolving therapies. Gene therapy is probably the most exciting one as it represents a curative approach.
(BELG J HEMATOL 2018;9(4):161–3)
Read moreBJH - volume 7, issue Abstract Book BHS, january 2016
B. Mahadeb , D. Noubouossie MD, L. Rozen PharmD, T. Besse-Hamme , A. Efira MD, P. Hermans MD, PhD, B. Gulbis MD, PhD, M.A. Azerad MD, A. Demulder MD, PhD
BJH - volume 6, issue 4, october 2015
O. Ketelslegers MD, F. Eyskens MD, PhD, F. Boemer PhD, V. Bours MD, PhD, J-M. Minon MD, PhD, B. Gulbis MD, PhD
Although neonatal screening for sickle cell disease is one of the best tools for reducing mortality during infancy and early childhood, it is not part of the approved neonatal screening programme in Belgium. As epidemiological data on sickle cell disease are still incomplete in Belgium, we planned to screen the samples of newborns available in the biggest reference centre for approved neonatal screening in Flanders. From July to December 2013, a total of 18,989 newborns from 36 Flemish maternity wards were systematically screened, representing about 60% of the total number of births in Flanders. For the same period, results of the neonatal screening that is routinely performed for sickle cell disease in three other Belgian centres were collected. Overall, 39,599 newborns were screened, representing about two-thirds of Belgian births for this period. With an incidence of sickle cell disease and sickle cell trait of 1/2,329 and 1/77, respectively, sickle cell disease is the most frequently inherited disease observed in the population tested; the highest incidences were registered in urban areas. In addition, screening techniques identified 122 other clinically significant haemoglobin (Hb) variant carriers (83 for HbC, twenty for HbE, thirteen for HbD-Punjab, and six for HbO-Arab) and two HbC diseases. Carriers of clinically significant Hb variants were observed in almost all the maternity wards included in the study, showing a wide dispersal of populations at risk. These epidemiological data remind us of the warnings and recommendations from the World Health Organization, urging policy-makers to consider the most appropriate strategy to prevent and treat patients with sickle cell disease in Belgium.
(BELG J HEMATOL 2015;6(4): 135–41)
Read moreBJH - 2014, issue Abstract Book BSTH, november 2014
L. Dewispelaere MD, B. Mahadeb , L. Rozen PharmD, D. Noubouossie MD, T. Besse-Hamer , A. Efira MD, P. Hermans MD, PhD, B. Gulbis MD, PhD, M.A. Azerad MD, A. Demulder MD, PhD
BJH - volume 4, issue 3, september 2013
A. Ferster MD, PhD, B. Gulbis MD, PhD
During the twelfth meeting dedicated to sickle cell disease and hereditary red cell disorders held in Brussels on 21 February 2013, several topics related to major aspects for the management of sickle cell disease were presented. Six of them are summarised.
(BELG J HEMATOL 2013;4(3): 115–116)
Read moreBJH - 2013, issue BHS Abstractbook, january 2013
P.-Q. Le , B. Gulbis MD, PhD, L. Dedeken , C. Heijmans , A. Vanderfaeillie MD, C. Vermylen , S. Huybrechts MD, C. Devalck , F. Cotton , B.C. Nguyen , F. Vertongen , M. Ngalula , A. Ferster MD, PhD
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