Articles

P26 Immunomagnetic enrichment of circulating tumor cells prior to tumor Ig specific qASO-PCR enhances the sensitivity of minimal residual disease detection in multiple myeloma

BJH - 2018, issue Abstract Book BHS, february 2018

W. De Brouwer , J. Van Der Straeten MSc, C. Demanet MD, PhD, H. Schots , M. Bakkus PhD, I. Van Riet PhD

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P1.10 Immunoglobulin and T-cell receptor gene analysis by next-generation sequencing

BJH - volume 7, issue Abstract Book BHS, january 2016

J. Van Der Straeten MSc, B. Caljon , C. Demanet MD, PhD, M.H.C. Bakkus

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Minimal residual disease quantification by PCR in childhood acute lymphoblastic leukaemia

BJH - volume 5, issue 3, september 2014

J. Van Der Straeten MSc, B. De Moerloose MD, PhD, M-F. Dresse MD, PhD, S. Dupont MD, A. Ferster MD, PhD, P. Philippet MD, A. Uyttebroeck MD, PhD, J. van der Werff ten Bosch MD, PhD, C. Demanet MD, PhD, Y Benoit MD, PhD, M. Bakkus PhD

Summary

In Belgium approximately 70 children are diagnosed with acute lymphoblastic leukaemia annually. For these children, the monitoring of minimal residual disease has an important prognostic value. The level of minimal residual disease during the first three months of therapy is used to recognise subgroups that differ substantially in outcome. Two techniques are used for minimal residual disease monitoring: the Genescan method and the allele specific oligonucleotide polymerase chain reaction. The Genescan method is a less sensitive method (10−3) but is fast and less expensive. The allele specific oligonucleotide polymerase chain reaction requires more time and budget but has a sensitivity of 10−4–10−5. Both techniques have proven their value in minimal residual disease monitoring in childhood acute lymphoblastic leukaemia.

(BELG J HEMATOL 2014;5(3):81–8)

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P2.09 Impact of minimal residual disease monitoring on therapy in Belgian childhood acute lymphoblastic leukaemia

BJH - volume 5, issue Abstract Book BHS, january 2014

J. Van Der Straeten MSc, B. De Moerloose MD, PhD, M-F. Dresse MD, PhD, S. Dupont MD, A. Ferster MD, PhD, P. Philippet MD, A. Uyttebroeck MD, PhD, J. Van der Werf ten Bosch , C. Demanet MD, PhD, Y Benoit MD, PhD, M. Bakkus PhD

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P.68 Heterosexual HIV-1 Transmission is Associated with Allogeneic KIR/HLA Ligand Combinations Governing Natural Killer Cell Alloreactivity

BJH - 2013, issue BHS Abstractbook, january 2013

W. Jennes , S. Verheyden , C. Demanet MD, PhD, J.W. Mertens , C. Camara , M. Seydi , T. Dieye , S. Mboup , L. Kestens

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