Articles

Multipotent mesenchymal stromal cell therapy for steroid-refractory acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

BJH - volume 7, issue 6, december 2016

S. Servais MD, PhD, C. Grégoire MD, F. Baron MD, PhD, E. Willems MD, PhD, A. Briquet PhD, E. Baudoux MD, O. Delloye PhD, O. Giet PhD, C. Lechanteur PhD, Y. Beguin MD, PhD

Summary

Steroid-refractory acute graft-versus-host disease is a severe complication after allogeneic stem cell transplantation. So far, its treatment remains very challenging since the current therapies do not offer significant benefits. Among the most recent approaches, multipotent mesenchymal stromal cell-based therapy has attracted great interest over the past decade. Here, we briefly reviewed the current knowledges about the immunomodulatory properties of multipotent mesenchymal stromal cells as well as results of preclinical and clinical studies having assessed their efficacy to modulate steroid-refractory acute graft-versus-host disease.

(BELG J HEMATOL 2016;7(6):229–35)

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Highlights in acute leukemia

BJH - volume 7, issue 1, february 2016

F. Baron MD, PhD

Summary

This report on the best ASH abstracts for acute leukemia will be divided into a section on acute myeloid leukemia (AML) and a second section on acute lymphoblastic leukemia (ALL).

(BELG J HEMATOL 2016; 7(1):27–30)

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O.4 SRC kinase inhibition with saracatinib limits the development of osteolytic bone disease in multiple myeloma

BJH - volume 7, issue Abstract Book BHS, january 2016

R. Heusschen PhD, J. Muller MSc, M. Binsfeld , E. Plougonven , N. Mahli , G. Carmeliet , A. Léonard , F. Baron MD, PhD, M. Cohen-Solal , K. Vanderkerken PhD, Y. Beguin MD, PhD, E. Menu , J. Caers MD, PhD

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PP2.1 Immunomodulatory effects of rapamycin in Graft versus Host Disease

BJH - volume 7, issue Abstract Book BHS, january 2016

G. Ehx , M. Hannon , S. Humblet-Baron , S. Dubois , C. Daulne , P. Drion , E. Willems MD, PhD, S. Servais MD, PhD, Y. Beguin MD, PhD, F. Baron MD, PhD

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PP3.1 Azacytidine prevents experimental sclerodermic chronic graft-versus-host disease

BJH - volume 7, issue Abstract Book BHS, january 2016

G. Fransolet , G. Ehx , J. Somja MD, L. Delens , M. Hannon , S. Dubois , P. Drion , J. Caers MD, PhD, S. Humblet-Baron , L. Belle , P. Delvenne , Y. Beguin MD, PhD, G. Conteduca , F. Baron MD, PhD

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PP3.2 Umbilical cord mesenchymal stromal cells are superior to bone marrow and adipose tissue-derived mesenchymal stromal cells for the treatment of xenogeneic graft-versus-host disease in mice

BJH - volume 7, issue Abstract Book BHS, january 2016

C. Grégoire MD, Y. Beguin MD, PhD, M. Hannon , S. Dubois , B. Baudoux , A. Briquet PhD, C. Lechanteur PhD, G. Ehx , F. Baron MD, PhD

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P2.06 Salt but not glucocorticosteroïds enhances Th17 differentiation from naïve T cells in vitro

BJH - volume 7, issue Abstract Book BHS, january 2016

L. Delens , S. Servais MD, PhD, L. Vrancken , G. Ehx , G. Fransolet , M. Hannon , S. Dubois , C. Daulne , Y. Beguin MD, PhD, F. Baron MD, PhD

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