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I. Van Riet PhD

Articles

P26 Immunomagnetic enrichment of circulating tumor cells prior to tumor Ig specific qASO-PCR enhances the sensitivity of minimal residual disease detection in multiple myeloma

BJH - 2018, issue Abstract Book BHS, february 2018

W. De Brouwer , J. Van Der Straeten MSc, C. Demanet MD, PhD, H. Schots , M. Bakkus PhD, I. Van Riet PhD

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P1.05 Exosomal miR-146a from multiple myeloma cells regulates cytokine and chemokine secretion in mesenchymal stromal cells

BJH - volume 7, issue Abstract Book BHS, january 2016

K. De Veirman , J. Wang , S. Xu , X. Leleu , E. Himpe , K. Maes , E. De Bruyne , E. Van Valckenborgh PhD, K. Vanderkerken PhD, E. Menu , I. Van Riet PhD

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P1.01 Myeloid Derived Suppressor Cells induce Multiple Myeloma cell survival through AMPK activation

BJH - volume 6, issue Abstract Book BHS, january 2015

K. De Veirman , J. van Ginderachter , N. De Beule , S. Lub , A. Maes , E. De Bruyne , E. Menu , I. Van Riet PhD, K. Vanderkerken PhD, E. Van Valckenborgh PhD

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P3.03 Study of immune recovery in a randomized phase II trial of sequential double autologous transplantation with unmanipulated or AC133+ PBSC in patients with multiple myeloma

BJH - volume 6, issue Abstract Book BHS, january 2015

M. Hannon , S. Servais MD, PhD, R. Schots MD, PhD, E. Castermans , L. Seidel , A. Gothot MD, PhD, E. Baudoux MD, O. Giet PhD, N. Wanten , E. Willems MD, PhD, C. Daulne , I. Van Riet PhD, Y. Beguin MD, PhD, F. Baron MD, PhD

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Biological properties of mesenchymal stem cells in the multiple myeloma tumour microenvironment

BJH - volume 5, issue 2, june 2014

X. Song MD, PhD, K. Vanderkerken PhD, I. Van Riet PhD

Summary

Mesenchymal stem cells are multipotent non-hematopoietic progenitor cells that are capable of differentiating into various mesenchymal tissues and give rise to most bone marrow stromal cells. Several studies have demonstrated that bone marrow derived mesenchymal stem cells from multiple myeloma patients are functionally and genetically abnormal compared to their normal counterparts. However, the direct involvement of mesenchymal stem cells in the pathophysiology of multiple myeloma remains unclear. In our research project we aimed to investigate how mesenchymal stem cells influence multiple myeloma cell growth and whether and at which level the differentiation of mesenchymal stem cells towards osteoblasts is impaired in this disease. Our data provided evidence that mesenchymal stem cells can stimulate tumour growth and disease evolution in multiple myeloma and are involved in the bone disease associated with this malignancy.

(BELG J HEMATOL 2014;5(2):64–7)

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P.32 The generation and activation of Myeloid-Derived Suppressor Cells in Multiple Myeloma

BJH - 2013, issue BHS Abstractbook, january 2013

K. De Veirman , E. De Bruyne , E. Menu , I. Van Riet PhD, K. Vanderkerken PhD, E. Van Valckenborgh PhD

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