BJH - volume 5, issue 4, december 2014
B. Hodossy MD, I. Vrelust MD, S. Anguille MD, PhD, V. Van Marck MD, PhD, M. Maes PhD, PharmD, K. Vermeulen PhD, A. Van de Velde MD, A. Gadisseur MD, PhD, W. Schroyens MD, PhD, Z. Berneman MD, PhD
We present the case of a 58-year-old male patient with a long-standing, intermittent oedema of the lower extremities and significant spontaneous variations in haematocrit values. Repeated examinations failed to reveal a clear etiology until the patient suffered from a severely painful exacerbation of leg oedema and hypotension. Laboratory analysis showed hypoalbuminemia. The combination of oedema, hypotension, hypoalbuminemia and hemoconcentration was indicative of a systemic capillary leak syndrome. This condition is known to be associated with monoclonal gammopathy, as was the case in our patient. New investigations showed suspicious lesions in the nasopharynx, scrotum and breast. Biopsies of this breast mass as well as bone marrow biopsy showed the presence of an extranodal natural killer/T-cell lymphoma, nasal type. Polychemotherapy was administered according to the SMILE schedule leading to a remission after two cycles. The patient then underwent autologous hematopoietic stem cell transplantation. The patient is currently without signs of systemic capillary leak syndrome. This report illustrates that systemic capillary leak syndrome may occur as a prodrome of haematological malignancies, such as natural killer/T-cell lymphoma and documents that it is responsive to chemotherapy.
(BELG J HEMATOL 2014;5(4):148–53)
Read moreBJH - volume 5, issue Abstract Book BHS, january 2014
S. Meers MD, PhD, D. Selleslag MD, Y. Beguin MD, PhD, C. Graux MD, PhD, G. Bries MD, PhD, D. Deeren , I. Vrelust MD, P. Pierre , C. Ravoet , K. Theunissen , F. Trullemans , L. Noens MD, PhD, P. Mineur MD
BJH - volume 4, issue 3, september 2013
L. Roosens PhD, K. Vermeulen PhD, A. Verlinden MD, H. Devos MD, E. Van Assche , I. Vrelust MD, M-B. Maes PhD, R. Malfait MD
Although a myeloid sarcoma is a rare form of extramedullary leukaemia, its early diagnosis has been proven to be of utmost importance. Its presence is strongly related to the onset or the presence of systemic bone marrow leukaemia. However, the diagnosis of myeloid sarcoma is not straightforward. In the existing literature, approximately half of the cases of myeloid sarcoma were initially misdiagnosed as lymphoma. The current case reports details on the laboratory diagnosis of myeloid sarcoma in a 25-year old male. The laboratory presentation of myeloid sarcoma and the consecutive steps in order to correctly diagnose myeloid sarcoma using a variety of laboratory techniques including microscopy, flow cytometry and cytogenetics are highlighted.
(BELG J HEMATOL 2013;4(3): 106–109)
Read moreBJH - 2013, issue BHS Abstractbook, january 2013
W. Schroyens MD, PhD, Z. Berneman MD, PhD, A. Gadisseur MD, PhD, A. Van de Velde MD, I. Vrelust MD
BJH - 2013, issue BHS Abstractbook, january 2013
I. Vrelust MD, E. Post , J. van Looveren , R. Malfait MD
BJH - 2013, issue BHS Abstractbook, january 2013
I. Bruynseels , S. Ceyssens , A. Van de Velde MD, W. Schroyens MD, PhD, A. Gadisseur MD, PhD, Z. Berneman MD, PhD, I. Vrelust MD
BJH - 2013, issue BHS Abstractbook, january 2013
B. Hodossy MD, S. Helsen , A. Verlinden MD, A. Van de Velde MD, A. Gadisseur MD, PhD, W. Schroyens MD, PhD, Z. Berneman MD, PhD, I. Vrelust MD
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