BJH - 2018, issue Abstract Book BHS, february 2018
J. Muller MSc, A. Bolomsky , S. Dubois , E. Duray , Y. Beguin MD, PhD, H. Ludwig , R. Heusschen PhD, J. Caers MD, PhD
BJH - volume 8, issue 2, march 2017
R. Heusschen PhD, J. Muller MSc, N. Withofs MD, PhD, F. Baron MD, PhD, Y. Beguin MD, PhD, J. Caers MD, PhD
Multiple myeloma bone disease is a major cause of morbidity and mortality in multiple myeloma patients and persists even in patients in remission. Multiple myeloma bone disease is caused by an uncoupling of bone remodelling, with increased osteoclast activity and decreased osteoblast activity, culminating in lytic bone destruction. Bisphosphonates are the current standard-of-care but new therapies are needed. As the molecular mechanisms controlling multiple myeloma bone disease are increasingly understood, new therapeutic targets are extensively explored in the preclinical setting and initial clinical trials with novel compounds show promising results. In this review, we provide a comprehensive overview of the biology of multiple myeloma bone disease, summarise its current clinical management and discuss preclinical and clinical data on next generation therapies.
(BELG J HEMATOL 2017;8(2):66–74)
Read moreBJH - volume 8, issue Abstract Book BHS, february 2017
R. Heusschen PhD, A. Bolomsky , K. Schlangen , K. Schönfelder , J. Muller MSc, W. Schreiner , N. Zojer , J. Caers MD, PhD, H. Ludwig
BJH - volume 8, issue Abstract Book BHS, february 2017
G. Ehx , G. Fransolet , L. Delens , J. Muller MSc, Y. Beguin MD, PhD, S. Humblet-Baron , M. Hannon , F. Baron MD, PhD
BJH - volume 8, issue Abstract Book BHS, february 2017
M. Hannon , C. Grégoire MD, J. Muller MSc, G. Fransolet , L. Delens , Y. Beguin MD, PhD, G. Ehx , F. Baron MD, PhD
BJH - volume 8, issue Abstract Book BHS, february 2017
J. Muller MSc, M. Binsfeld , S. Dubois , G. Carmeliet , Y. Beguin MD, PhD, R. Heusschen PhD, J. Caers MD, PhD
BJH - volume 7, issue Abstract Book BHS, january 2016
R. Heusschen PhD, J. Muller MSc, M. Binsfeld , E. Plougonven , N. Mahli , G. Carmeliet , A. Léonard , F. Baron MD, PhD, M. Cohen-Solal , K. Vanderkerken PhD, Y. Beguin MD, PhD, E. Menu , J. Caers MD, PhD
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