BJH - volume 7, issue 5, october 2016
K. Vanhouteghem PharmD, H. Vanhouteghem PharmD, K. De Schynkel MD, K. Van Haver MD, J. Dierick MD, A. Luyckx MD, PhD
Summary
Neonatal thrombocytopenia comprises a platelet count of less than 150×109/L, with severe neonatal thrombocytopenia in case of a platelet count less than 50×109/L. Severe thrombocytopenia is an uncommon finding in newborns requiring immediate diagnostic work-up with the need for urgent intervention to avoid severe bleeding complications. Neonatal thrombocytopenia can be classified by time of onset in early-onset (<72h after birth) versus late-onset (>72h after birth) thrombocytopenia. Multiple causes may be involved. In term, otherwise healthy neonates, one important cause of early-onset thrombocytopenia is antibody-mediated platelet destruction, and this can be allo- or auto-immune-mediated. In this case presentation, we discuss two neonates with severe early-onset immune-mediated thrombocytopenia presenting simultaneously at our general hospital.
(BELG J HEMATOL 2016;7(5):188–93)
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