Articles

Update on the initial therapy of multiple myeloma

BJH - volume 5, issue 4, december 2014

M-C. Vekemans MD, K. Beel MD, PhD, J. Caers MD, PhD, N. Meuleman MD, PhD, G. Bries MD, PhD, V. Delrieu MD, H. Demuynck MD, B. De Prijck MD, H. De Samblanx MD, A. Deweweire MD, A. Kentos MD, P. Mineur MD, F. Offner MD, PhD, I. Vande Broek MD, PhD, A. Vande Velde MD, J. Van Droogenbroeck MD, PhD, KL. Wu MD, PhD, C. Doyen MD, PhD, R. Schots MD, PhD, M. Delforge MD, PhD

Summary

With the introduction of immunomodulatory drugs and proteasome inhibitors, major improvements have been achieved in the treatment and prognosis of multiple myeloma. Different treatment combinations are now in use and innovative therapies are being developed. This rapidly changing therapeutic landscape calls for an update on the Belgian myeloma guidelines, published in 2010.1 Based on an extensive review of the recent literature, the myeloma study group of the Belgian Hematology Society has revised the consensus recommendations on myeloma care, to be used by haematologists as a reference for daily practice. When applicable, comments with regards to the Belgian reimbursement modalities are included. The full text with appendices can be downloaded from the Belgian Hematology Society website (www.bhs.be) and from the Belgium Journal of Hematology website (www.ariez.com).

(BELG J HEMATOL 2014;5(4):125–36)

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Syndrome of inappropriate antidiuretic hormone secretion associated with bortezomib

BJH - volume 5, issue 3, september 2014

P. Mineur MD, F. Hubert , E. Van den Neste MD, PhD, K. Peeters PhD

Summary

We observed severe hyponatremia in a patient who was treated with bortezomib for multiple myeloma. The patient was diagnosed with the syndrome of inappropriate secretion of antidiuretic hormone due to bortezomib.

(BELG J HEMATOL 2014;5(3):104–5)

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P2.01 Downregulation of cellular microRNA-150 is a new prognostic factor associated with a poor prognosis in Chronic Lymphocytic Leukemia patients

BJH - volume 5, issue Abstract Book BHS, january 2014

B. Stamatopoulos , N. Meuleman MD, PhD, E. Crompot , M. Van Damme , B. Dessars MD, PhD, H. El Housni , P. Mineur MD, D. Bron MD, PhD, L. Lagneaux

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P2.05 Global HDAC enzymatic activity is a strong marker of poor prognosis in Chronic Lymphocytic Leukemia

BJH - volume 5, issue Abstract Book BHS, january 2014

M. Van Damme , E. Crompot , N. Meuleman MD, PhD, P. Mineur MD, B. Dessars MD, PhD, H. El Housni , D. Bron MD, PhD, L. Lagneaux , B. Stamatopoulos

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P3.05 Efficacy of azacitidine in Belgian patients: results of a real-life non-interventional, post-marketing survey

BJH - volume 5, issue Abstract Book BHS, january 2014

S. Meers MD, PhD, D. Selleslag MD, Y. Beguin MD, PhD, C. Graux MD, PhD, G. Bries MD, PhD, D. Deeren , I. Vrelust MD, P. Pierre , C. Ravoet , K. Theunissen , F. Trullemans , L. Noens MD, PhD, P. Mineur MD

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Disease characteristics in Belgian myelofibrosis patients and management guidelines anno 2013

BJH - volume 4, issue 4, december 2013

T. Devos MD, PhD, N. Straetmans MD, PhD, C. Schuermans MD, S. Benghiat MD, PhD, V. Robin MD, P. Lewalle MD, PhD, P. Mineur MD, G. Verhoef MD, PhD, L. Knoops MD, PhD

Summary

Diagnostic and management guidelines for myelofibrosis patients are presented in this paper. As a consequence of the rapid evolution and progress in this domain over the last years, the need was felt by the BHS MPN subcommittee to update these guidelines for our country. The different prognostic scores in myelofibrosis, the diagnostic tools and treatment options with the focus on new possibilities are discussed.

(BELG J HEMATOL 2013;4(4): 127–137)

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P.04 HDAC in Chronic Lymphocytic Leukaemia: expression profile, enzymatic activity and prognostic significance

BJH - 2013, issue BHS Abstractbook, january 2013

M. Van Damme , E. Crompot , N. Meuleman MD, PhD, P. Mineur MD, D. Bron MD, PhD, L. Lagneaux , B. Stamatopoulos

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