Articles

P3.04 Screening JAK2 V617F-negative Essential Thrombocytosis Patients for Mutations in SESN2, DNAJC17, ST13, TOP1MT, and NTRK1

BJH - volume 5, issue Abstract Book BHS, january 2014

C. AL Assaf , E. Lierman PhD, T. Devos MD, PhD, C. Graux MD, PhD, J. Billiet MD, P. Papadopoulos , P. Vandenberghe MD, PhD

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O.1 Exome sequencing identifies mutation of the ribosome in T-ALL

BJH - 2013, issue BHS Abstractbook, january 2013

K. de Keersmaecker , Z. Kalender Atak , N. Li , C. Vicente , S. Patchett , T. Girardi , V. Gianfelici , E. Geerdens , M. Porcu , I. Lahortiga , R. Luca , J. Yan , G. Hulselmans , E. Clappier , R. Vandepoel , B. Sweron , K. Jacobs PhD, N. Mentens , I. Wlodarska , B. Cauwelier MD, PhD, J. Cloos , J. Soulier , A. Uyttebroeck MD, PhD, C. Bagni , B. Hassan , P. Vandenberghe MD, PhD, A. Johnson , S. Aerts , J. Cools

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P.09 Exome sequencing identifies mutation of CNOT3 in T-cell acute lymphoblastic leukaemia

BJH - 2013, issue BHS Abstractbook, january 2013

C. Vicente , K. de Keersmaecker , Z. Kalender Atak , J. Yan , N. Li , V. Gianfelici , E. Geerdens , E. Clappier , G. Hulselmans , R. Vande poel , B. Cauwelier MD, PhD, J. Cloos , J. Soulier , A. Uyttebroeck MD, PhD, B. Hassan , P. Vandenberghe MD, PhD, S. Aerts , J. Cools

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P.10 Role of HH pathway in T cell acute lymphoblastic leukaemia (T-ALL)

BJH - 2013, issue BHS Abstractbook, january 2013

A. Dagklis , D. Pauwels , I. Lahortiga , Z.K. Atak , K. de Keersmaecker , K. Jacobs PhD, N. Mentens , A. Uyttebroeck MD, PhD, J. Maertens MD, PhD, G. Verhoef MD, PhD, S. Aerts , P. Vandenberghe MD, PhD, J. Cools

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Concomitant JAK2 V617F positive essential thrombocytemia and BCR-ABL1 positive chronic myeloid leukaemia masked by imatinib therapy for a gastrointestinal stromal tumour

BJH - volume 3, issue 3, september 2012

E. Del Biondo MD, H. De Raeve MD, PhD, G. Huysmans MD, K. Hendrickx MD, E. Wouters MD, P. Vandenberghe MD, PhD, P. Meeus MD

Summary

The coincidence of a Janus Kinase 2 (JAK2) V617F positive myeloproliferative neoplasm (MPN) and a BCR-ABL1 positive chronic myeloid leukaemia (CML) is rare. We present a patient whose bone marrow and peripheral blood showed typical features of essential thrombocytemia (ET). However, the normalisation of the white blood cell (WBC) count after therapy with imatinib for a gastrointestinal stromal tumour (GIST) suggests that an underlying CML was masked, as witnessed by the very low levels of BCR-ABL1 at the haematological diagnosis. The question remains if this is a case of two separate myeloid malignancies or a secondary event (BCR-ABL1 fusion) in a primary JAK2 V617F + ET.

(BELG J HEMATOL 2012:3:105–107)

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