Articles

Highlights in lymphoma

BJH - volume 9, issue 1, february 2018

S. Snauwaert MD, PhD

SUMMARY

This non-comprehensive summary of abstracts dedicated to lymphoma that were presented at ASH 2017, will focus on Hodgkin lymphoma (HL), follicular lymphoma (FL), primary central nervous system lymphoma (PCNSL) and diffuse large B-cell lymphoma (DLBCL). Although this selection of abstracts is of course biased by personal interest, it aims to give you a relevant overview for daily clinical practice.

(BELG J HEMATOL 2018;9(1):14–8)

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O.4 In vitro generation of tumor antigen-specific T cells from patient and healthy donor stem cells

BJH - volume 8, issue Abstract Book BHS, february 2017

S. Bonte , S. Snauwaert MD, PhD, G. Goetgeluk , B. Vandekerckhove MD, PhD, T. Kerre MD, PhD

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PP4.5 Functional in vitro evaluation of T cells generated from minor H antigen-TCR transduced human hematopoietic stem cells using the OP9-DL1 coculture system

BJH - volume 7, issue Abstract Book BHS, january 2016

S. Bonte , S. Snauwaert MD, PhD, M. Heemskerk , B. Vandekerckhove MD, PhD, T. Kerre MD, PhD

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P2.01 Functional evaluation of T cells generated from WT1-TCR transduced human hematopoietic stem cells using the OP9-DL1 coculture system

BJH - volume 6, issue Abstract Book BHS, january 2015

S. Bonte , S. Snauwaert MD, PhD, G. Goetgeluk , M.H.M. Heemskerk , H. Stauss , R. Stripecke , B. Vandekerckhove MD, PhD, T. Kerre MD, PhD

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In vitro generation of AML-specific T-cells from human haematopoietic progenitor cells. A step towards curing acute myeloid leukaemia?

BJH - volume 5, issue 4, december 2014

S. Snauwaert MD, PhD, B. Vandekerckhove MD, PhD, T. Kerre MD, PhD

Summary

This dissertation focuses on T-cell-mediated immunotherapeutic strategies for the treatment of acute myeloid leukaemia. Two major key points determine the success of adoptive T-cell therapy: the nature of the target antigen and the characteristics of the infused T-cells. We reviewed potential acute myeloid leukaemia target antigens and performed an in-depth study of the Receptor for Hyaluronic Acid Mediated Motility as a potential leukaemia associated antigen. Subsequently, an alternative immunotherapeutic strategy was studied: the in vitro generation of antigen-specific T-cells starting from T-cell receptor-transduced human haematopoietic progenitor cells.

(BELG J HEMATOL 2014;5(4):154–7)

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O.5 In vitro generation of antigen-specific T-cells from hematopoietic progenitor cells: a new and promising immunotherapeutic strategy

BJH - 2013, issue BHS Abstractbook, january 2013

S. Snauwaert MD, PhD, G. Goetgeluk , S. van Coppernolle , G. Verstichel , Y. Van Caeneghem , S. Vanhee , I. Velghe , J. Plum , B. Vandekerckhove MD, PhD, T. Kerre MD, PhD

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P.54 Establishment of transgenic human embryonic stem cell lines for the study of human hematopoiesis

BJH - 2013, issue BHS Abstractbook, january 2013

S. Vanhee , K. De Mulder , Y. Van Caeneghem , I. Velghe , S. Snauwaert MD, PhD, G. Verstichel , G. Goetgeluk , T. Kerre MD, PhD, B. Vandekerckhove MD, PhD

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