BJH - volume 7, issue Abstract Book BHS, january 2016
G. Fransolet , G. Ehx , J. Somja MD, L. Delens , M. Hannon , S. Dubois , P. Drion , J. Caers MD, PhD, S. Humblet-Baron , L. Belle , P. Delvenne , Y. Beguin MD, PhD, G. Conteduca , F. Baron MD, PhD
BJH - volume 7, issue Abstract Book BHS, january 2016
G. Ehx , M. Hannon , S. Humblet-Baron , S. Dubois , C. Daulne , P. Drion , E. Willems MD, PhD, S. Servais MD, PhD, Y. Beguin MD, PhD, F. Baron MD, PhD
BJH - volume 7, issue Abstract Book BHS, january 2016
J. Muller MSc, M. Binsfeld , S. Dubois , G. Carmeliet , Y. Beguin MD, PhD, R. Heusschen PhD, J. Caers MD, PhD
BJH - volume 7, issue Abstract Book BHS, january 2016
S. Servais MD, PhD, D. Selleslag MD, J. Maertens MD, PhD, L. Lechanteur , E. Baudoux MD, P. Zachée MD, PhD, H. Schouten , L. Noens MD, PhD, P. Lewalle MD, PhD, W. Schroyens MD, PhD, A. Ory , Y. Beguin MD, PhD
BJH - volume 6, issue 4, october 2015
S. Servais MD, PhD, F. Baron MD, PhD, Y. Beguin MD, PhD
Since many graft-related factors may affect outcomes after allogeneic stem cell transplantation, graft selection is one of the crucial steps of transplant preparation. Optimal graft selection may offer the best chance of successful transplantation. Here, we reviewed the impact of graft-related factors on post transplant outcomes in light of new data that may help to refine the strategy for graft and graft source selection.
(BELG J HEMATOL 2015;6(4): 162–8)
Read moreBJH - volume 6, issue 2, may 2015
C. Bonnet MD, PhD, A. Janssens MD, PhD, K.L. Wu MD, PhD, W. Schroyens MD, PhD, V. Van Hende MD, P. Heimann MD, PhD, T. Tousseyn MD, PhD, M. André MD, D. Bron MD, PhD, A. Van Hoof MD, PhD, G. Verhoef MD, PhD, B. De Prijck MD, Y. Beguin MD, PhD, D. Dierickx MD, PhD
Burkitt’s lymphoma is a rare but very aggressive non-Hodgkin’s lymphoma characterised by an isolated translocation t(8;14)(q24;q32). The sporadic form is the sub-entity most frequently encountered in Belgium. Diagnosis and initial work-up must be completed rapidly to start treatment as soon as possible. Positron emission tomography scan is useful for initial staging and to evaluate the chemosensitivity of the tumour during and after treatment. After debulking, it is recommended to add rituximab to chemotherapy. Currently intensive short-cycle and low intensity chemotherapies are two valuable options. Radiotherapy is not indicated except in case of central nervous system involvement. Patients achieving complete remission must be followed carefully during the first year to detect recurrence of the disease. More than 80% of patients sustain their remission one year following initial treatment and are considered cured. For patients in partial remission or with chemosensitive relapse, autologous stem cell transplantation is recommended following re-induction with non-cross-resistant polychemotherapy. Monitoring complete blood counts and cognitive functions is important to detect late toxicity of the applied therapies.
(BELG J HEMATOL 2015;6(2):61–9)
Read moreBJH - volume 6, issue 2, may 2015
S. Sid MD, C. Dugauquier MD, B. De Prijck MD, C. Bonnet MD, PhD, Y. Beguin MD, PhD
We present a patient with Burkitt’s lymphoma who suffered a severe haemolytic crisis after treatment with rasburicase. This case report underlines the high incidence of glucose-6-phosphate dehydrogenase deficiency in some ethnic groups and the importance of a detailed patient and family history before starting treatment, even in case of emergency. Glucose-6-phosphate dehydrogenase is an essential enzyme since it makes the synthesis of NADPH + H from NADP possible, which determines the reducing power (NADPH) of the cell. Every defect in this physiological process, notably glucose-6-phosphate dehydrogenase deficiency, may thus result simultaneously with the use of rasburicase in acute or chronic haemolysis according to the importance of the deficiency. Management is based on stopping the incriminated drug and on supportive therapy consisting of administering packed red blood cells if the anaemia is poorly tolerated.
(BELG J HEMATOL 2015;6(2): 74–8)
Read more
Top
